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  • The black car in which Tupac was fatally shot is...

    Malcolm Payne/Getty Images

    The black car in which Tupac was fatally shot is seen behind police tape at the crime scene in Las Vegas, Nevada. Suge Knight was also in the car with Tupac, but he survived the shooting.

  • Snoop Dogg and Tupac Shakur were not only friends, they...

    John Roca/Getty Images

    Snoop Dogg and Tupac Shakur were not only friends, they were also musical collaborators. The duo released the song "2 Of Amerikaz Most Wanted" in 1996. They are pictured here at the MTV Video Music Awards at Radio City in New York City the same year.

  • Prior to his 1996 murder, rapper Tupac Shakur enjoyed a...

    Raymond Boyd/Getty Images

    Prior to his 1996 murder, rapper Tupac Shakur enjoyed a celebrated, albeit short music and acting career, thanks to release of albums like "All Eyez on Me" and "Me Against the World," and roles in movies including "Juice" and "Poetic Justice". He was also a key figure in the East Coast, West Coast hip-hop rivalry. Here, Tupac, inked with his famous "Thug Life" tattoo, performs in 1994 during a concert in Chicago.

  • On Nov. 30, 1994, Tupac was on his way to...

    Eric Miller/AP

    On Nov. 30, 1994, Tupac was on his way to Quad Studios in New York City to record a rap when he was ambushed, robbed and shot five times. He is pictured here in a wheelchair on Dec. 1, 1994, arriving at Manhattan Supreme Court after miraculously surviving the attack.

  • Tupac Shakur speaks as fellow rap artist Snoop Dogg listens...

    Frank Wiese/AP

    Tupac Shakur speaks as fellow rap artist Snoop Dogg listens during a voter registration rally in South Central Los Angeles on Aug. 15, 1996.

  • Born Alice Faye Williams in North Carolina, she changed her...

    New York Daily News Archive

    Born Alice Faye Williams in North Carolina, she changed her name to Afeni Shakur when she became a member of the Black Panthers. She was accused of taking part in numerous bombings as part of the revolutionary black nationalist and socialist organization and was arrested in 1969.

  • Jada Pinkett was Tupac's best friend throughout his life. The...

    Kevin Mazur Archive/WireImage

    Jada Pinkett was Tupac's best friend throughout his life. The two met in high school in Baltimore and quickly became friends, maintaining their close relationship up until his death.

  • In 1993, Tupac Shakur was charged with sexually assaulting a...

    Justin Sutcliffe/AP

    In 1993, Tupac Shakur was charged with sexually assaulting a woman, although he denied it. Here, he is led from the Manhattan North police precinct after being arrested in an alleged sexual attack on Nov. 19, 1993.

  • This photo shows the intersection of Harmon and Las Vegas...

    Jack Dempsey/AP

    This photo shows the intersection of Harmon and Las Vegas Blvd. in Las Vegas on Sept. 8, 1996, the day after Tupac Shakur was shot in a drive-by while riding with Suge Knight.

  • Tupac accompanied Rosie Perez to the Soul Train Music Awards...

    Ron Galella/Wireimage

    Tupac accompanied Rosie Perez to the Soul Train Music Awards on March 9, 1993. In a 2015 interview with Howard Stern, Perez shared that Tupac took her to the award show after he learned that her original date stood her up.

  • Tupac Shakur posed with rappers Notorious B.I.G. and Redman backstage...

    Al Pereira/Getty Images

    Tupac Shakur posed with rappers Notorious B.I.G. and Redman backstage at his show at the Palladium on July 23, 1993, in New York City. Although they seem friendly here, Tupac and Notorious B.I.G. later had an ongoing rivalry, which began when Biggie released the song "Who Shot Ya?," which Tupac assumed was about him.

  • Despite his major contribution to the world of music, Tupac...

    Kevin Mazur/WireImage

    Despite his major contribution to the world of music, Tupac surprisingly never won a Grammy. He is pictured here at the 1996 Grammys with Kiss, where he was nominated for Best Rap Solo Performance for his hit "Dear Mama" and Best Rap Album for "Me Against the World."

  • Rappers Tupac Shakur, Snoop Doggy Dogg and Hammer joined the...

    Frank Wiese/AP

    Rappers Tupac Shakur, Snoop Doggy Dogg and Hammer joined the black-activists group Brotherhood Crusade on Aug. 15, 1996, in Los Angeles to kick off a campaign against the "three-strikes" law and to oppose the California Civil Rights Initiative, the anti-affirmative action measure.

  • Tupac Shakur's mother, Afeni Shakur, speaks to the audience during...

    Annette Brown/Getty Images

    Tupac Shakur's mother, Afeni Shakur, speaks to the audience during a tribute to her son at the Nick Cannon Hosts Boost Mobile Rockcorps Volunteers Concert at Fox Theater June 16, 2006 in Atlanta, Georgia.

  • Snoop Dogg and Tupac Shakur were pictured leaving the 23rd...

    Kevin Mazur/WireImage

    Snoop Dogg and Tupac Shakur were pictured leaving the 23rd Annual American Music Awards on Jan. 29, 1996.

  • Tupac Shakur, who was fatally shot in 1996, celebrated his...

    Ron Galella/WireImage

    Tupac Shakur, who was fatally shot in 1996, celebrated his mother's accomplishments in the 1995 song "Dear Mama."

  • Tupac Shakur in a scene from the film "Gridlock'd" in...

    Gramercy Pictures/Archive Photos/Getty Images

    Tupac Shakur in a scene from the film "Gridlock'd" in 1997.

  • A black BMW, riddled with bullet holes, is seen in...

    Lennox McLendon/AP

    A black BMW, riddled with bullet holes, is seen in a Las Vegas police impound lot in a file photo from Sept. 8, 1996. Rapper Tupac Shakur was shot while riding in the car driven by Death Row Records Chairman Marion "Suge" Knight on Sept. 7, 1996, and died a week later.

  • Afeni Shakur is survived by her daughter Sekyiwa. While it...

    Annette Brown/Getty Images

    Afeni Shakur is survived by her daughter Sekyiwa. While it is believed she suffered a possible cardiac arrested, her cause of death is yet to be determined by The Marin County Sheriff's Coroner's Office.

  • Afeni Shakur is comforted by her sister Gloria Cox while...

    Annette Brown/Getty Images

    Afeni Shakur is comforted by her sister Gloria Cox while watching the African drum ceremony on September 9, 2006, to mark the 10 year anniversary of her her late son's death in Stone Mountain, Georgia.

  • Afeni Shakur acted as her own criminal defense attorney after...

    New York Daily News Archive/Getty Images

    Afeni Shakur acted as her own criminal defense attorney after being accussed of being involved in numerous bombings at busy city landmarks in 1969. Here, she pictured leaving the Ciminal Courts Buidling with fellow Black Panther member Richard Moore (left) and his wife Iris (center).

  • On Sept. 7, 1996, Tupac was fatally shot in a...

    New York Daily News

    On Sept. 7, 1996, Tupac was fatally shot in a drive-by shooting in Las Vegas, where he was attending a boxing match with Suge Knight. The rapper succumbed to his injuries six days later, and the front page of the Daily News on Sept. 14, 1996, read, "Rap Requiem: Tupac Shakur dies of gunshot wounds."

  • Political and social activist and Black Panther member Afeni Shakur...

    David Fenton/Getty Images

    Political and social activist and Black Panther member Afeni Shakur (center) shares a laugh with Dhoruba Bin Wahad (center right, in tortoise-shell glasses) at a rally in support of the Panther 21, New York, New York, April 4, 1970. The Panther 21 were Black Panther members arrested by New York police under suspicion of planning a series of bombings, charges that were eventually dropped against all the defendents.

  • Rapper Tupac Shakur posed for a mug shot for the...

    Michael Ochs Archives/Getty Images

    Rapper Tupac Shakur posed for a mug shot for the New York State Department of Corrections after his conviction for the sexual abuse of a female fan on March 8, 1995, in New York, New York. He was sentenced to 1.5 to 4.5 years in prison, but only served nine months.

  • In addition to his hip hop career, Tupac was also...

    Orion/Archive Photos/Getty Images

    In addition to his hip hop career, Tupac was also an actor. He is pictured here in a scene from the movie "Gang Related" with James Belushi, which was released after his death in 1997.

  • In this famous photo of Tupac, the rapper spit at...

    Bebeto Matthews/AP

    In this famous photo of Tupac, the rapper spit at reporters as he left the Supreme Court in New York on July 5, 1994.

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Afeni Shakur, the former Black Panther who overcame drug addiction and inspired the work of her rap icon son Tupac Shakur before guiding his estate after his murder, has died. She was 69.

Marin County sheriff’s deputies and firefighters responded to Shakur’s houseboat in Sausalito, Calif., Monday night after she fell ill and suffered a suspected heart attack, police said.

A family member and a close friend were present when she became unresponsive, cops said.

“At this point, there is nothing to indicate to us that there was any foul play, nothing suspicious about this other than this being sadly a natural event,” Marin County Sheriff’s Lt. Doug Pittman said.

Paramedics arrived around 9:30 p.m., and Shakur was rushed to Marin General Hospital, where she was treated for about an hour before she was pronounced dead, according to Pittman.

An autopsy was scheduled for Tuesday.

Afeni Shakur (seen in June 2011) has died aged 69, after a suspected heart attack.
Afeni Shakur (seen in June 2011) has died aged 69, after a suspected heart attack.

“It’s a sad day,” Tupac’s biological dad, Billy Garland, told the Daily News. “Her contributions to this world will always be remembered. We weren’t really active in each other’s lives, but the pain is magnified when it’s the mother of your child.”

TUPAC SHAKUR DIES DAYS AFTER DRIVE-BY SHOOTING IN 1996

The New Jersey trucker, 66, recalled Shakur as a strong woman. He lamented their court battle after Tupac’s death in 1996, which ended with a judge denying his inheritance claim in 1997 because he contributed little to the superstar’s upbringing.

“We had a lot of legal issues that got blown out of proportion, and I regret that,” he told The News. “It’s just a shock that she’s gone. I hope she’ll be at peace.”

Shakur, born Alice Faye Williams in Lumberton, N.C., changed her name when she moved to New York City and joined the Black Panther movement. She and other party members were arrested in 1969 and charged with conspiracy to bomb multiple city landmarks.

In May 1971, Shakur was acquitted on all charges after she represented herself in court while heavily pregnant. She gave birth to Tupac a month later.

Shakur was the subject of her son’s 1995 hit song “Dear Mama,” which hailed her triumph over poverty and drug addiction.

“There’s no way I can pay you back/But the plan is to show you that I understand/You are appreciated,” he rapped.

After Tupac’s 1996 shooting death, Shakur took the helm of his estate, which earns more than $1 million a year. She has funneled much of the money to charity.

“She was a remarkable woman. In her youth she was a lion in the black movement. She was indefatigable,” Richard Fischbein, a New York lawyer who worked with her in the Bronx when Tupac was a young boy, told The News.

Tupac Shakur, who was fatally shot in 1996, celebrated his mother’s accomplishments in the 1995 song “Dear Mama.”

Shakur called Fischbein after Tupac’s death, and he became the administrator of the estate.

“She guided that estate in honor of Tupac. We must have put out five albums after he died. She took a lot of that money and spent her time trying to help young black kids, and kids in general,” he said.

Shakur is survived by daughter Sekyiwa Shakur, 40, who was living on a nearby houseboat. A source told The News it was Sekyiwa who called 911.

LOVE LETTER TUPAC SHAKUR PENNED IN HIGH SCHOOL SELLING FOR $35K

Fischbein said Sekyiwa likely will take over the estate and foundation created in Tupac’s name.

Afeni (l.) and Tupac Shakur are seen together in the 2003 documentary “Tupac: Resurrection.”

“She is going to do a great job. She’ll follow Aseni’s wishes, I’m sure,” he said.

Dina LaPolt, a California attorney who handled Tupac Shakur’s estate for nearly 10 years, fought back tears as she described Shakur, who inspired the lawyer to open up her own firm in 2001.

“She’s an advocate. She’s an activist. She taught me never to compromise your values — to always fight for what you believe in,” she told The News.

LaPolt oversaw the legal work behind 11 posthumously released albums while she represented the estate between 2001 and 2010.

The lawyer developed a close professional relationship with Shakur, who LaPolt described as “one of the smartest people I’ve ever worked with,” citing how the Black Panther represented herself in court. The activist mother also influenced LaPolt’s personal life, she said.

“I met her when I was 91 days sober. Now I’m 18 years sober,” she said. “She was very, very instrumental in my life. I carry her with me to this day.”

Earlier this year, Shakur filed for divorce from her husband of 12 years, Gust Davis, and was allegedly in a legal battle over her son’s fortune, TMZ reported. Davis demanded half of the $20,000 Shakur took home every month.

A man who answered Davis’ cell phone Tuesday said he was not speaking to the press.

In 2014, Shakur co-produced “Holler If Ya Hear Me,” a Broadway jukebox musical featuring her son’s works.

A movie about Tupac’s life, “All Eyez on Me,” is set for release in November, with Danai Gurira cast as Shakur. Shakur served as an executive producer for the film.

With Flo Anthony

ndillon@nydailynews.com